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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.21.000
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.505
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.462
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.459
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.454
2w05FRTCyclin-dependent kinase 22.7.11.220.448
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.444
4id71G0Activated CDC42 kinase 1/0.442