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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3uibSB2Putative mitogen-activated protein kinase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3uibSB2Putative mitogen-activated protein kinase/1.000
3dt1P40Mitogen-activated protein kinase 14/0.505
3hp552PMitogen-activated protein kinase 14/0.493
1bl6SB6Mitogen-activated protein kinase 14/0.492
3itzP66Mitogen-activated protein kinase 14/0.488
3fklFKLMitogen-activated protein kinase 14/0.487
3iphG11Mitogen-activated protein kinase 14/0.486
2y6o1N1Ephrin type-A receptor 42.7.10.10.483
2balPQAMitogen-activated protein kinase 14/0.481
3flzFLZMitogen-activated protein kinase 14/0.480
3nww3NWMitogen-activated protein kinase 14/0.480
3u8w09JMitogen-activated protein kinase 14/0.479
1ywrLI9Mitogen-activated protein kinase 14/0.478
3ds6A17Mitogen-activated protein kinase 14/0.478
3flwFLWMitogen-activated protein kinase 14/0.478
3uvqFS8Mitogen-activated protein kinase 14/0.475
3fskRO6Mitogen-activated protein kinase 14/0.473
3flyFLYMitogen-activated protein kinase 14/0.471
3hllI45Mitogen-activated protein kinase 14/0.471
3flsFLSMitogen-activated protein kinase 14/0.470
2zb0GK3Mitogen-activated protein kinase 14/0.469
3fmh533Mitogen-activated protein kinase 14/0.469
3zsh469Mitogen-activated protein kinase 14/0.469
4aa4QC0Mitogen-activated protein kinase 14/0.468
4kip1R9Mitogen-activated protein kinase 14/0.467
3gfeP37Mitogen-activated protein kinase 14/0.465
3mpaSB2Mitogen-activated protein kinase 14/0.464
3s4qNK0Mitogen-activated protein kinase 14/0.464
2itqITQEpidermal growth factor receptor2.7.10.10.462
2zb1GK4Mitogen-activated protein kinase 14/0.462
3gc9B45Mitogen-activated protein kinase 112.7.11.240.462
2ft9CHDFatty acid-binding protein 2, liver/0.460
4lopSB4Mitogen-activated protein kinase 14/0.460
2gfsPQBMitogen-activated protein kinase 14/0.459
4aacAAVMitogen-activated protein kinase 14/0.459
3fln3FNMitogen-activated protein kinase 14/0.457
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.454
3ha85JZMitogen-activated protein kinase 14/0.454
3lfa1N1Mitogen-activated protein kinase 14/0.454
1ouk084Mitogen-activated protein kinase 14/0.453
2qo9ANPEphrin type-A receptor 32.7.10.10.453
3fmjFMJMitogen-activated protein kinase 14/0.453
3hl7I47Mitogen-activated protein kinase 14/0.453
2itwITQEpidermal growth factor receptor2.7.10.10.452
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.452
4gk2L66Ephrin type-A receptor 32.7.10.10.452
3lfcZ86Mitogen-activated protein kinase 14/0.451
2b53D23Cyclin-dependent kinase 22.7.11.220.450
2rg6287Mitogen-activated protein kinase 14/0.450
1zzlTZYMitogen-activated protein kinase 14/0.449
1u4dDBQActivated CDC42 kinase 1/0.448
3hub469Mitogen-activated protein kinase 14/0.448
4aa5NQBMitogen-activated protein kinase 14/0.448
4gk4L90Ephrin type-A receptor 32.7.10.10.448
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
3ocgOCGMitogen-activated protein kinase 14/0.447
2zjwREFCasein kinase II subunit alpha2.7.11.10.445
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.443
2jcxNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.442
3vjoANPEpidermal growth factor receptor2.7.10.10.441
2vx07X7Ephrin type-B receptor 42.7.10.10.440
2znq401Peroxisome proliferator-activated receptor delta/0.440
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.440