sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3t70 | DU4 | Deoxyuridine 5'-triphosphate nucleotidohydrolase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3t70 | DU4 | Deoxyuridine 5'-triphosphate nucleotidohydrolase | / | 1.000 | |
| 3t64 | DU3 | Deoxyuridine 5'-triphosphate nucleotidohydrolase | / | 0.605 | |
| 4wrk | DUP | DUTPase | / | 0.517 | |
| 2xy3 | DUP | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.510 | |
| 2y1t | DUD | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.491 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.480 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.468 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.464 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.459 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.459 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.459 | |
| 5ao1 | DG3 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.455 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.454 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.454 | |
| 3i8p | 840 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.453 | |
| 4xfj | ANP | Argininosuccinate synthase | / | 0.452 | |
| 2oke | DUP | DUTP pyrophosphatase | / | 0.450 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.450 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.450 | |
| 4zwm | PLP | Ornithine aminotransferase, mitochondrial, putative | / | 0.450 | |
| 4bqz | GNP | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.449 | |
| 1tka | N3T | Transketolase 1 | 2.2.1.1 | 0.448 | |
| 2q9c | GNP | Signal recognition particle receptor FtsY | / | 0.447 | |
| 2r5n | TPP | Transketolase 1 | / | 0.446 | |
| 2a2x | NA9 | Prothrombin | 3.4.21.5 | 0.445 | |
| 3phj | DHK | Shikimate dehydrogenase (NADP(+)) | / | 0.443 | |
| 4hmx | FMN | Pyridoxamine 5'-phosphate oxidase | / | 0.443 | |
| 1ja0 | NAP | NADPH--cytochrome P450 reductase | / | 0.442 | |
| 1ra3 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.442 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.441 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.441 | |
| 2jh0 | 701 | Prothrombin | 3.4.21.5 | 0.440 | |
| 3r43 | ID8 | Aldo-keto reductase family 1 member C3 | / | 0.440 |