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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3qyw6PBMitogen-activated protein kinase 12.7.11.24

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3qyw6PBMitogen-activated protein kinase 12.7.11.241.000
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.514
1tvoFRZMitogen-activated protein kinase 12.7.11.240.507
4fv9E71Mitogen-activated protein kinase 12.7.11.240.483
4h3qANPMitogen-activated protein kinase 12.7.11.240.477
4g6oE28Mitogen-activated protein kinase 12.7.11.240.472
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.464
1k6pXN3Gag-Pol polyprotein3.4.23.160.462
4g6nEK0Mitogen-activated protein kinase 12.7.11.240.462
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
2ijmATPFocal adhesion kinase 12.7.10.20.461
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.459
4fv0EK3Mitogen-activated protein kinase 12.7.11.240.458
2j0lANPFocal adhesion kinase 12.7.10.20.451
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.450
4fv4EK7Mitogen-activated protein kinase 12.7.11.240.450
4b99R4LMitogen-activated protein kinase 72.7.11.240.449
1k6tXN1Gag-Pol polyprotein3.4.23.160.447
2oji33AMitogen-activated protein kinase 12.7.11.240.446
2ojj82AMitogen-activated protein kinase 12.7.11.240.446
3fzr3JZProtein-tyrosine kinase 2-beta2.7.10.20.444
4s34ANPMitogen-activated protein kinase 12.7.11.240.444
3cgoJNOMitogen-activated protein kinase 102.7.11.240.443
4k8aK8AFocal adhesion kinase 12.7.10.20.442
4s32ANPMitogen-activated protein kinase 12.7.11.240.442
1w8cN69Cyclin-dependent kinase 22.7.11.220.441
2r3gSC9Cyclin-dependent kinase 22.7.11.220.441
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.441
4fv8E63Mitogen-activated protein kinase 12.7.11.240.440