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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3qcjNX4Receptor-type tyrosine-protein phosphatase gamma3.1.3.48

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3qcjNX4Receptor-type tyrosine-protein phosphatase gamma3.1.3.481.000
3qckNX5Receptor-type tyrosine-protein phosphatase gamma3.1.3.480.635
3qclNXVReceptor-type tyrosine-protein phosphatase gamma3.1.3.480.601
3qchNX2Receptor-type tyrosine-protein phosphatase gamma3.1.3.480.560
3qciNX3Receptor-type tyrosine-protein phosphatase gamma3.1.3.480.531
3oagLPQRenin3.4.23.150.455
3qm4PN0Cytochrome P450 2D6/0.455
3eon341Glutaryl-CoA dehydrogenase/0.454
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.450
3g70A5TRenin3.4.23.150.447
1o8cNDPProbable acrylyl-CoA reductase AcuI1.3.1.840.445
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.445
3k1wBFXRenin3.4.23.150.443
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
1xddAAYIntegrin alpha-L/0.442
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
4fw05KJNitric oxide synthase, brain1.14.13.390.442
2po7CHDFerrochelatase, mitochondrial4.99.1.10.441
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441