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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3p5kP5KMitogen-activated protein kinase 14

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3p5kP5KMitogen-activated protein kinase 14/1.000
3p7bP7BMitogen-activated protein kinase 14/0.805
3p79P79Mitogen-activated protein kinase 14/0.679
3o8uBMUMitogen-activated protein kinase 14/0.642
2puuG2GMitogen-activated protein kinase 14/0.604
3uvr06FMitogen-activated protein kinase 14/0.586
3hv71AUMitogen-activated protein kinase 14/0.570
3k3jF4CMitogen-activated protein kinase 14/0.558
3nnuEDBMitogen-activated protein kinase 14/0.553
3gi3B10Mitogen-activated protein kinase 14/0.551
1kv1BMUMitogen-activated protein kinase 14/0.546
3nnxEDDMitogen-activated protein kinase 14/0.545
3wzeBAXVascular endothelial growth factor receptor 22.7.10.10.541
1kv2B96Mitogen-activated protein kinase 14/0.532
3npcB96Mitogen-activated protein kinase 92.7.11.240.527
3kq7KQ7Mitogen-activated protein kinase 14/0.519
3e9319BMitogen-activated protein kinase 14/0.512
3gcuR48Mitogen-activated protein kinase 14/0.512
1wbsLI2Mitogen-activated protein kinase 14/0.511
3hv6R39Mitogen-activated protein kinase 14/0.510
1wbtWBTMitogen-activated protein kinase 14/0.500
4aa0AA0Mitogen-activated protein kinase 14/0.500
4l8mF46Mitogen-activated protein kinase 14/0.494
3hv4L51Mitogen-activated protein kinase 14/0.492
1wbvLI3Mitogen-activated protein kinase 14/0.489
3p78P78Mitogen-activated protein kinase 14/0.486
3lfbZ87Mitogen-activated protein kinase 14/0.474
3p7aP7AMitogen-activated protein kinase 14/0.474
3ugc046Tyrosine-protein kinase JAK2/0.469
2yisYISMitogen-activated protein kinase 14/0.467
3p7cP7CMitogen-activated protein kinase 14/0.466
3cs9NILTyrosine-protein kinase ABL12.7.10.20.458
4u0i0LIMast/stem cell growth factor receptor Kit2.7.10.10.455
3nnwEDDMitogen-activated protein kinase 14/0.453
2e2b406Tyrosine-protein kinase ABL12.7.10.20.445
4h4rFADBiphenyl dioxygenase ferredoxin reductase subunit/0.442
3vhe42QVascular endothelial growth factor receptor 22.7.10.10.440