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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3oyzACOMalate synthase2.3.3.9

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3oyzACOMalate synthase2.3.3.91.000
4l9zCOAL-malyl-CoA/beta-methylmalyl-CoA lyase4.1.3.240.514
4l9y1VUL-malyl-CoA/beta-methylmalyl-CoA lyase4.1.3.240.495
4yt5H4MH(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338/0.478
4l801VUMalyl-CoA/beta-methylmalyl-CoA/citramalyl-CoA lyase4.1.3.240.476
2gq3COAMalate synthase G/0.465
3saz043Malate synthase G/0.463
2uxoTACHTH-type transcriptional regulator TtgR/0.458
4ia7BIVVitamin D3 receptor A/0.458
4nmbFADBifunctional protein PutA/0.458
2j5xGSPADP-ribosylation factor 6/0.451
4ia2BIVVitamin D3 receptor A/0.450
3l0lHC3Nuclear receptor ROR-gamma/0.449
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.449
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.448
3t2kFADSulfide-quinone reductase/0.448
1sozVAL_TYR_GLN_PHESerine endoprotease DegS3.4.21.1070.445
3ds6A17Mitogen-activated protein kinase 14/0.445
3s56ROCProtease/0.445
2znq401Peroxisome proliferator-activated receptor delta/0.443
1zg32HIIsoflavone 4'-O-methyltransferase/0.441
2m56CAMCamphor 5-monooxygenase1.14.15.10.441