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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3k5uPFQAurora kinase A2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3k5uPFQAurora kinase A2.7.11.11.000
5l8lADPAurora kinase A2.7.11.10.555
4o0uADNAurora kinase A2.7.11.10.523
4jboWPHAurora kinase A2.7.11.10.504
4jbpYPHAurora kinase A2.7.11.10.499
3efwAK8Aurora kinase A2.7.11.10.498
4c3pACPAurora kinase A2.7.11.10.465
5dosATPAurora kinase A2.7.11.10.464
4o0wADNAurora kinase A2.7.11.10.462
4deeADPAurora kinase A2.7.11.10.460
2wqeADPAurora kinase A2.7.11.10.443
4jbqVX6Aurora kinase A2.7.11.10.443