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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3i3sGNPGTPase HRas

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3i3sGNPGTPase HRas/1.000
5b2zGNPGTPase HRas/0.676
3lbnGNPGTPase HRas/0.653
3rs5GNPGTPase HRas/0.636
3oivGNPGTPase HRas/0.627
3v4fGNPGTPase HRas/0.627
3oiuGNPGTPase HRas/0.612
4dltGNPGTPase HRas/0.604
3rs7GNPGTPase HRas/0.601
4dlwGNPGTPase HRas/0.601
3ddcGNPGTPase HRas/0.586
4mitGTPRho-related protein racC/0.576
3l8yGNPGTPase HRas/0.563
1zc4GNPRas-related protein Ral-A/0.558
3kucGDPRas-related protein Rap-1A/0.557
1kmqGNPTransforming protein RhoA/0.548
3rabGNPRas-related protein Rab-3A/0.542
4nyjGNPGTPase HRas/0.542
3kkoGNPRas-related protein M-Ras/0.537
4lhwGNPRas-related protein Rab-8A/0.537
1cxzGSPTransforming protein RhoA/0.536
2gcpGSPRho-related GTP-binding protein RhoC/0.533
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.532
1zc3GNPRas-related protein Ral-A/0.525
3kz1GSPTransforming protein RhoA/0.524
3tsoGNPRas-related protein Rab-25/0.521
4nyiGNPGTPase HRas/0.518
1g17GNPRas-related protein SEC4/0.517
1xtsGTPGTP-binding protein Rheb/0.517
4dsuGDPGTPase KRas/0.515
5dhaGNPGTP-binding nuclear protein Ran/0.515
1m7bGTPRho-related GTP-binding protein RhoE/0.513
1xtrGNPGTP-binding protein Rheb/0.508
3pitGNPRas-related protein M-Ras/0.506
4dxaGSPRas-related protein Rap-1b/0.506
1t91GTPRas-related protein Rab-7a/0.505
3nbzGTPGTP-binding nuclear protein Ran/0.503
2rgeGNPGTPase HRas/0.502
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.502
5hpyGDPTransforming protein RhoA/0.501
1uadGNPRas-related protein Ral-A/0.500
4kvgGTPRas-related protein Rap-1A/0.499
2rgcGNPGTPase HRas/0.498
1ibrGNPGTP-binding nuclear protein Ran/0.496
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.495
4qxaGTPRas-related protein Rab-9A/0.495
4rkfGNPRas-related protein Rab-3/0.495
1oixGDPRas-related protein Rab-11A/0.493
3ea5GDPGTP-binding nuclear protein Ran/0.490
3e5hGNPRas-related protein Rab-28/0.489
5jljGNPGTP-binding nuclear protein Ran/0.489
3a58GNPGTP-binding protein RHO1/0.487
3lbhGNPGTPase HRas/0.487
1zbdGTPRas-related protein Rab-3A/0.485
3x1zGNPRas-related protein Rap-1b/0.485
2zetGTPRas-related protein Rab-27B/0.482
3rs0GNPGTPase HRas/0.481
1yhnGTPRas-related protein Rab-7a/0.480
3rs4GNPGTPase HRas/0.478
4g0nGNPGTPase HRas/0.478
1ow3GDPTransforming protein RhoA/0.475
3oesGNPGTPase RhebL1/0.475
2c5lGTPGTPase HRas/0.474
4xoiGTPTransforming protein RhoA/0.474
2cl6CAGGTPase HRas/0.473
3eg5GNPCell division control protein 42 homolog/0.473
3rslGNPGTPase HRas/0.472
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.472
4dlzGNPGTPase HRas/0.471
1yzqGNPRas-related protein Rab-6A/0.469
4cymGCPRas-related protein Rab-32/0.469
3w3zGTPGTP-binding nuclear protein Ran/0.467
3oiwGNPGTPase HRas/0.466
4dlxGNPGTPase HRas/0.464
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.463
4o25GTPGTP-binding protein Rheb/0.463
2rgbGNPGTPase HRas/0.462
3lbiGNPGTPase HRas/0.462
3a6pGTPGTP-binding nuclear protein Ran/0.460
2gilGTPRas-related protein Rab-6A/0.459
1s1cGNPTransforming protein RhoA/0.458
3bc1GNPRas-related protein Rab-27A/0.458
1e96GTPRas-related C3 botulinum toxin substrate 1/0.455
3bbpGTPRas-related protein Rab-6A/0.455
4dlvGNPGTPase HRas/0.455
1z0aGDPRas-related protein Rab-2A/0.454
1zd9GDPADP-ribosylation factor-like protein 8A/0.452
4dsnGCPGTPase KRas/0.452
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.451
3qbtGNPRas-related protein Rab-8A/0.451
4dsoGSPGTPase KRas/0.448
2clsGTPRho-related GTP-binding protein Rho6/0.447
4hdqGNPRas-related protein Rap-1b/0.447
4js0GNPCell division control protein 42 homolog/0.447
1lfdGNPGTPase HRas/0.446
2fe4GDPRas-related protein Rab-6B/0.444
1z2cGNPRho-related GTP-binding protein RhoC/0.443
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.443
4uj3GNPRas-related protein Rab-11A/0.443
2gvdGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.441
3tgpGNPGTPase HRas/0.441
3th5GNPRas-related C3 botulinum toxin substrate 1/0.441