sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3htj | ET | EbrA repressor |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3htj | ET | EbrA repressor | / | 1.000 | |
| 3hth | PRL | EbrA repressor | / | 0.500 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.489 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.472 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.469 | |
| 3cth | 319 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.465 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.459 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.455 | |
| 3vjc | ZGA | Squalene synthase | 2.5.1.21 | 0.453 | |
| 1fml | RTL | Retinol dehydratase | / | 0.452 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.452 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.452 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.451 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
| 1yc2 | NAD | NAD-dependent protein deacylase 2 | / | 0.448 | |
| 2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.446 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 3tky | N7I | (Iso)eugenol O-methyltransferase | 2.1.1.146 | 0.444 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.443 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 2i9p | NAD | 3-hydroxyisobutyrate dehydrogenase, mitochondrial | 1.1.1.31 | 0.441 | |
| 4equ | G6I | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.441 | |
| 4gqk | ADP | Actin cross-linking toxin VgrG1 | / | 0.441 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 4yx6 | FMN | Omega-3 polyunsaturated fatty acid synthase subunit PfaD | / | 0.440 |