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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3hthPRLEbrA repressor

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3hthPRLEbrA repressor/1.000
3htjETEbrA repressor/0.526
2fs4PZ1Renin3.4.23.150.453
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.453
1v08NTZ4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.451
4jpg1OXPyruvate kinase PKM2.7.1.400.448
1jf2CZHObelin/0.446
3hf8ML0Tryptophan 5-hydroxylase 11.14.16.40.443
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.443