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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3hp552PMitogen-activated protein kinase 14

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3hp552PMitogen-activated protein kinase 14/1.000
3uvqFS8Mitogen-activated protein kinase 14/0.604
3mpaSB2Mitogen-activated protein kinase 14/0.602
3ha85JZMitogen-activated protein kinase 14/0.543
3roc29AMitogen-activated protein kinase 14/0.537
3hub469Mitogen-activated protein kinase 14/0.530
3ds6A17Mitogen-activated protein kinase 14/0.528
4eym0RXMitogen-activated protein kinase 132.7.11.240.525
3fskRO6Mitogen-activated protein kinase 14/0.524
4nka2K7Fibroblast growth factor receptor 1/0.524
3fknFKNMitogen-activated protein kinase 14/0.523
3zsh469Mitogen-activated protein kinase 14/0.519
3fl4FL4Mitogen-activated protein kinase 14/0.514
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.511
2zb1GK4Mitogen-activated protein kinase 14/0.500
3flwFLWMitogen-activated protein kinase 14/0.499
2gfsPQBMitogen-activated protein kinase 14/0.497
3fkoFKOMitogen-activated protein kinase 14/0.485
2ghmLICMitogen-activated protein kinase 14/0.476
3s4qNK0Mitogen-activated protein kinase 14/0.476
3uibSB2Putative mitogen-activated protein kinase/0.476
4lopSB4Mitogen-activated protein kinase 14/0.476
3sgx0FWDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.475
2zb0GK3Mitogen-activated protein kinase 14/0.473
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.473
3c5uP41Mitogen-activated protein kinase 14/0.471
3hng8STVascular endothelial growth factor receptor 12.7.10.10.469
3l8p0CEAngiopoietin-1 receptor2.7.10.10.467
4kaoKAOFocal adhesion kinase 12.7.10.20.466
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.463
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.462
1bl6SB6Mitogen-activated protein kinase 14/0.461
1zyjBI5Mitogen-activated protein kinase 14/0.461
3dt1P40Mitogen-activated protein kinase 14/0.461
3gc9B45Mitogen-activated protein kinase 112.7.11.240.461
3nww3NWMitogen-activated protein kinase 14/0.461
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.460
1w84L12Mitogen-activated protein kinase 14/0.459
2qd9LGFMitogen-activated protein kinase 14/0.459
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.459
3fmkFMKMitogen-activated protein kinase 14/0.458
2ww4ADP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.457
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.456
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.456
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.454
3o8tBMUMitogen-activated protein kinase 14/0.454
4g1wG1WMitogen-activated protein kinase 82.7.11.240.453
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.452
3ttiKBIMitogen-activated protein kinase 102.7.11.240.451
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.451
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.451
4o2z046Mitogen-activated protein kinase/0.450
1osvCHCBile acid receptor/0.449
1zzlTZYMitogen-activated protein kinase 14/0.449
2y03Y01Beta-1 adrenergic receptor/0.449
3tqhNDPQuinone oxidoreductase/0.449
1hvyD16Thymidylate synthase2.1.1.450.448
2c7xNRBCytochrome P450 monooxygenase PikC/0.448
3fc152PMitogen-activated protein kinase 14/0.448
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.448
1ouy094Mitogen-activated protein kinase 14/0.447
2w05FRTCyclin-dependent kinase 22.7.11.220.447
3cukFADD-amino-acid oxidase1.4.3.30.447
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.447
2ph5NADHomospermidine synthase/0.446
3flyFLYMitogen-activated protein kinase 14/0.446
3qa2XNAKetohexokinase/0.446
3zxtACPDeath-associated protein kinase 12.7.11.10.446
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.446
4hfmNAP2-alkenal reductase (NADP(+)-dependent)/0.446
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.445
4aa5NQBMitogen-activated protein kinase 14/0.445
4h3c0YZDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.445
4nk92K5Fibroblast growth factor receptor 1/0.445
3lfbZ87Mitogen-activated protein kinase 14/0.444
3nux3NVCyclin-dependent kinase 62.7.11.220.444
4ubsDIFPentalenic acid synthase1.14.15.110.444
3at4CCKCasein kinase II subunit alpha2.7.11.10.443
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.443
3fmh533Mitogen-activated protein kinase 14/0.443
3icrCOACoenzyme A disulfide reductase/0.443
3iqeF42F420-dependent methylenetetrahydromethanopterin dehydrogenase1.5.98.10.443
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.443
4g6hNAIRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.443
4s33ANPMitogen-activated protein kinase 12.7.11.240.443
2fgkATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.442
3v013V0Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.442
3vhkBPKVascular endothelial growth factor receptor 22.7.10.10.442
4c2uANPDNA helicase/0.442
1ywrLI9Mitogen-activated protein kinase 14/0.441
2c6eHPMAurora kinase A2.7.11.10.441
2gekGDPPhosphatidyl-myo-inositol mannosyltransferase2.4.1.570.441
3fln3FNMitogen-activated protein kinase 14/0.441
3flzFLZMitogen-activated protein kinase 14/0.441
3v04V04Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.441
4hys1BJMitogen-activated protein kinase 82.7.11.240.441
4icyFADPgaE/0.441
2cduFADNADH oxidase/0.440
2zgzGNPPlasmid segregation protein ParM/0.440
3fklFKLMitogen-activated protein kinase 14/0.440
3fmwFADOxygenase/0.440
3mec65BGag-Pol polyprotein2.7.7.490.440
4aseAV9Vascular endothelial growth factor receptor 22.7.10.10.440
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.440