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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3erkSB4Mitogen-activated protein kinase 12.7.11.24

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3erkSB4Mitogen-activated protein kinase 12.7.11.241.000
2c6eHPMAurora kinase A2.7.11.10.489
4gt3ATPMitogen-activated protein kinase 12.7.11.240.477
1tvoFRZMitogen-activated protein kinase 12.7.11.240.475
4b99R4LMitogen-activated protein kinase 72.7.11.240.463
2ojj82AMitogen-activated protein kinase 12.7.11.240.460
4fuxE75Mitogen-activated protein kinase 12.7.11.240.454
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.451
4fv9E71Mitogen-activated protein kinase 12.7.11.240.444
4id71G0Activated CDC42 kinase 1/0.442
4o0uADNAurora kinase A2.7.11.10.441