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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3el2ATPActin-5C

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3el2ATPActin-5C/1.000
4k43ADPActin, alpha skeletal muscle/0.594
1eqyATPActin, alpha skeletal muscle/0.584
4k42ADPActin, alpha skeletal muscle/0.579
3tu5ATPActin, alpha skeletal muscle/0.573
4cbxATPActin-2/0.570
1rgiATPActin, alpha skeletal muscle/0.568
4k41ATPActin, alpha skeletal muscle/0.567
2q36ATPActin, alpha skeletal muscle/0.566
4pkgATPActin, alpha skeletal muscle/0.565
1t44ATPActin, alpha skeletal muscle/0.563
1s22ATPActin, alpha skeletal muscle/0.556
3mn7ATPActin-5C/0.556
1qz5ATPActin, alpha skeletal muscle/0.553
1yxqATPActin, alpha skeletal muscle/0.544
1dejATPMajor actin/0.533
3eksATPActin-5C/0.526
4ci6ATPActin/0.525
4pl8ATPActin, alpha skeletal muscle/0.524
3dawATPActin, alpha skeletal muscle/0.523
3a5mATPMajor actin/0.522
1mduATPActin, alpha skeletal muscle/0.521
2oanATPActin, cytoplasmic 1/0.510
2p9kATPActin-related protein 2/0.503
3u9dATPActin, alpha skeletal muscle/0.493
2q97ATPActin, alpha skeletal muscle/0.481
1nlvATPMajor actin/0.445
1wuaATPActin, alpha skeletal muscle/0.442