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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3chwATPMajor actin

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3chwATPMajor actin/1.000
4jhdANPActin-5C/0.582
3m6gATPActin, alpha skeletal muscle/0.578
1c0fATPMajor actin/0.551
3mn9ATPActin-5C/0.547
4pkhADPActin, alpha skeletal muscle/0.542
4k42ADPActin, alpha skeletal muscle/0.531
1nlvATPMajor actin/0.530
1lotATPActin, alpha skeletal muscle/0.520
3mn6ATPActin-5C/0.517
4pl8ATPActin, alpha skeletal muscle/0.517
2q36ATPActin, alpha skeletal muscle/0.499
3ffkATPActin, alpha skeletal muscle/0.497
4pkgATPActin, alpha skeletal muscle/0.496
4rwtANPActin-5C/0.494
1nmdATPMajor actin/0.492
1h1vATPActin, alpha skeletal muscle/0.489
5ce3ATPActin/0.486
2v51ATPActin, alpha skeletal muscle/0.485
3tu5ATPActin, alpha skeletal muscle/0.485
1ijjATPActin, alpha skeletal muscle/0.477
4m63ATPActin-5C/0.475
3ekuATPActin-5C/0.468
1qz5ATPActin, alpha skeletal muscle/0.466
1wuaATPActin, alpha skeletal muscle/0.462
2q97ATPActin, alpha skeletal muscle/0.458
1nm1ATPMajor actin/0.450
3m1fATPActin, alpha skeletal muscle/0.449
1kxpATPActin, alpha skeletal muscle/0.447
4ci6ATPActin/0.445