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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3atyFMNProstaglandin F2a synthase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3atyFMNProstaglandin F2a synthase/1.000
4e2dFMNDehydrogenase/0.649
3atzFMNProstaglandin F2a synthase/0.637
4e2bFMNDehydrogenase/0.576
4jicFMNGTN Reductase/0.495
2abbFMNPentaerythritol tetranitrate reductase/0.493
4a3uFMNNADH:flavin oxidoreductase/NADH oxidase/0.491
1h50FMNPentaerythritol tetranitrate reductase/0.468
1h63FMNPentaerythritol tetranitrate reductase/0.464
3f03FMNPentaerythritol tetranitrate reductase/0.457
1icsFMN12-oxophytodienoate reductase 11.3.1.420.456
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.453
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.451
1vyrFMNPentaerythritol tetranitrate reductase/0.449
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.449
2hs6FMN12-oxophytodienoate reductase 31.3.1.420.448
3p67FMNPentaerythritol tetranitrate reductase/0.446
3p82FMNPentaerythritol tetranitrate reductase/0.442
3cib314Beta-secretase 13.4.23.460.440
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.440