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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3a4pDFQHepatocyte growth factor receptor2.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3a4pDFQHepatocyte growth factor receptor2.7.10.11.000
4gg70J8Hepatocyte growth factor receptor2.7.10.10.559
3zze6XPHepatocyte growth factor receptor2.7.10.10.555
4ap7F47Hepatocyte growth factor receptor2.7.10.10.522
2wgjVGHHepatocyte growth factor receptor2.7.10.10.521
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.478
4deg0JJHepatocyte growth factor receptor2.7.10.10.476
1u4dDBQActivated CDC42 kinase 1/0.472
4lm5Q17Serine/threonine-protein kinase pim-12.7.11.10.472
2jedLG8Protein kinase C theta type2.7.11.130.468
1xjdSTUProtein kinase C theta type2.7.11.130.466
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.464
4gg50J3Hepatocyte growth factor receptor2.7.10.10.464
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.456
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.455
4lmuQUESerine/threonine-protein kinase pim-12.7.11.10.455
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.454
4aoi4K0Hepatocyte growth factor receptor2.7.10.10.454
1u54ACPActivated CDC42 kinase 1/0.453
3zxzKRWHepatocyte growth factor receptor2.7.10.10.453
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.450
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.448
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.447
3uixQ17Serine/threonine-protein kinase pim-12.7.11.10.446
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.445
2xj1XJ1Serine/threonine-protein kinase pim-12.7.11.10.444
4at3LTIBDNF/NT-3 growth factors receptor2.7.10.10.441