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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2zbwFADFerredoxin--NADP reductase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2zbwFADFerredoxin--NADP reductase/1.000
3ab1FADFerredoxin--NADP reductase1.18.1.20.581
3lzxFADFerredoxin--NADP reductase 21.18.1.20.538
3rnmFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.461
1ebdFADDihydrolipoyl dehydrogenase1.8.1.40.459
4gcmFADThioredoxin reductase1.8.1.90.459
3ctyFADProbable thioredoxin reductase/0.451
3cib314Beta-secretase 13.4.23.460.449
4mo2FADUDP-galactopyranose mutase/0.448
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.447
1d4cFADFumarate reductase flavoprotein subunit1.3.5.40.446
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.445
2i0zFADNAD(FAD)-utilizing dehydrogenases/0.445
2wf4ZY4Beta-secretase 13.4.23.460.445
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.445
1c6yMK1Protease/0.444
1qo8FADFumarate reductase flavoprotein subunit/0.444
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.444
4a6cQG9Gag-Pol polyprotein3.4.23.160.444
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.443
3ixj586Beta-secretase 13.4.23.460.443
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.442
4em4FADCoenzyme A disulfide reductase/0.442
2avvMK1Gag-Pol polyprotein3.4.23.160.441
1rftPXMPyridoxal kinase2.7.1.350.440