sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2ywv	ADP	Phosphoribosylaminoimidazole-succinocarboxamide synthase

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
2ywv	ADP	Phosphoribosylaminoimidazole-succinocarboxamide synthase	/	1.000
4o7l	ADP	Phosphoribosylaminoimidazole-succinocarboxamide synthase	6.3.2.6	0.504
4o7n	ADP	Phosphoribosylaminoimidazole-succinocarboxamide synthase	6.3.2.6	0.489
2z02	ATP	Phosphoribosylaminoimidazole-succinocarboxamide synthase	6.3.2.6	0.471
4dc0	NDP	Putative ketoacyl reductase	1.3.1	0.456
2y1o	T26	UDP-N-acetylmuramoylalanine--D-glutamate ligase	6.3.2.9	0.455
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.450
4jaj	XU1	Aurora kinase A	2.7.11.1	0.450
2jed	LG8	Protein kinase C theta type	2.7.11.13	0.448
4wuc	ANP	DNA gyrase subunit B	/	0.446
1jm6	ADP	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	2.7.11.2	0.445
1lp4	ANP	Casein kinase II subunit alpha	2.7.11.1	0.443
2i0y	5CN	Macrophage colony-stimulating factor 1 receptor	2.7.10.1	0.442
3iqf	E4M	F420-dependent methylenetetrahydromethanopterin dehydrogenase	1.5.98.1	0.441
4hnc	0UT	Mandelate racemase	/	0.441
1q41	IXM	Glycogen synthase kinase-3 beta	2.7.11.26	0.440
3zw3	ZW3	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.440