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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2wbbRO3Fructose-1,6-bisphosphatase 13.1.3.11

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2wbbRO3Fructose-1,6-bisphosphatase 13.1.3.111.000
2wbdRO5Fructose-1,6-bisphosphatase 13.1.3.110.579
2y5kYCUFructose-1,6-bisphosphatase 13.1.3.110.519
2fhyA37Fructose-1,6-bisphosphatase 13.1.3.110.509
1xe55FEPlasmepsin-23.4.23.390.478
4q73FADBifunctional protein PutA/0.462
2vhwNAIAlanine dehydrogenase1.4.1.10.460
2znnS44Peroxisome proliferator-activated receptor alpha/0.458
1y4lSVRBasic phospholipase A2 homolog 2/0.451
4q71FADBifunctional protein PutA/0.448
2ahrNAPPyrroline-5-carboxylate reductase/0.445
2vhvNAIAlanine dehydrogenase1.4.1.10.445
1lbcCYZGlutamate receptor 2/0.444
2cig1DGDihydrofolate reductase1.5.1.30.442
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.441
2vhzNAIAlanine dehydrogenase1.4.1.10.441
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.441
4loqSB4Mitogen-activated protein kinase 14/0.440