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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2vgpAD6Aurora kinase B-A2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2vgpAD6Aurora kinase B-A2.7.11.11.000
3ztxZTXAurora kinase B-A2.7.11.10.614
2vrx447Aurora kinase B-A2.7.11.10.576
2c6eHPMAurora kinase A2.7.11.10.467
5l8lADPAurora kinase A2.7.11.10.458
3lijANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands/0.453
3cyw017Gag-Pol polyprotein3.4.23.160.445
4c3pACPAurora kinase A2.7.11.10.444
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.441
1k6cMK1Gag-Pol polyprotein3.4.23.160.440