sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2v7a	627	Tyrosine-protein kinase ABL1	2.7.10.2

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
2v7a	627	Tyrosine-protein kinase ABL1	2.7.10.2	1.000
4jia	1K3	Tyrosine-protein kinase JAK2	/	0.491
4hvi	19S	Tyrosine-protein kinase JAK3	2.7.10.2	0.455
4k8a	K8A	Focal adhesion kinase 1	2.7.10.2	0.447
1qcf	PP1	Tyrosine-protein kinase HCK	2.7.10.2	0.446
1qpj	STU	Tyrosine-protein kinase Lck	2.7.10.2	0.446
2j0l	ANP	Focal adhesion kinase 1	2.7.10.2	0.445
3lpb	NVB	Tyrosine-protein kinase JAK2	/	0.444
2x2l	X2L	Proto-oncogene tyrosine-protein kinase receptor Ret	2.7.10.1	0.443