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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pciSAHDiphthine synthase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2pciSAHDiphthine synthase/1.000
2ek2SAHDiphthine synthase/0.653
2dsiSAHDiphthine synthase/0.636
2p6iSAHDiphthine synthase/0.635
2e4nSAHDiphthine synthase/0.634
2eniSAHDiphthine synthase/0.631
2ehlSAHDiphthine synthase/0.629
2p5fSAHDiphthine synthase/0.628
2owkSAHDiphthine synthase/0.627
2dxwSAHDiphthine synthase/0.626
2e08SAHDiphthine synthase/0.626
2e7rSAHDiphthine synthase/0.626
2p6dSAHDiphthine synthase/0.625
2e07SAHDiphthine synthase/0.624
2el0SAHDiphthine synthase/0.624
2p5cSAHDiphthine synthase/0.624
2owuSAHDiphthine synthase/0.623
2dekSAHDiphthine synthase/0.620
2ejkSAHDiphthine synthase/0.620
2eleSAHDiphthine synthase/0.619
2egbSAHDiphthine synthase/0.615
2owgSAHDiphthine synthase/0.615
2pckSAHDiphthine synthase/0.615
2dxxSAHDiphthine synthase/0.614
2emuSAHDiphthine synthase/0.614
2e8qSAHDiphthine synthase/0.613
2e8rSAHDiphthine synthase/0.613
2pcgSAHDiphthine synthase/0.613
1vceSAHDiphthine synthase/0.612
2ek7SAHDiphthine synthase/0.612
2emrSAHDiphthine synthase/0.612
2dv4SAHDiphthine synthase/0.609
2dxvSAHDiphthine synthase/0.609
2ed5SAHDiphthine synthase/0.609
2p6kSAHDiphthine synthase/0.609
2eh2SAHDiphthine synthase/0.608
2z6rSAHDiphthine synthase/0.608
2e17SAHDiphthine synthase/0.607
2e8hSAHDiphthine synthase/0.607
2eglSAHDiphthine synthase/0.607
2eh4SAHDiphthine synthase/0.607
2pb6SAHDiphthine synthase/0.607
2dshSAHDiphthine synthase/0.606
2e16SAHDiphthine synthase/0.606
2ejjSAHDiphthine synthase/0.606
2ekaSAHDiphthine synthase/0.606
2p2xSAHDiphthine synthase/0.605
2dsgSAHDiphthine synthase/0.604
2dv5SAHDiphthine synthase/0.604
2eeqSAHDiphthine synthase/0.604
2eh5SAHDiphthine synthase/0.603
2el3SAHDiphthine synthase/0.603
2pb5SAHDiphthine synthase/0.603
2dv3SAHDiphthine synthase/0.602
1wngSAHDiphthine synthase/0.601
2ek3SAHDiphthine synthase/0.600
2huvSAHDiphthine synthase/0.600
2dv7SAHDiphthine synthase/0.599
2e15SAHDiphthine synthase/0.599
2en5SAHDiphthine synthase/0.599
2egsSAHDiphthine synthase/0.598
2p6lSAHDiphthine synthase/0.597
2pcmSAHDiphthine synthase/0.596
2huqSAHDiphthine synthase/0.594
2e8sSAHDiphthine synthase/0.591
2huxSAHDiphthine synthase/0.589
2owvSAHDiphthine synthase/0.589
2pb4SAHDiphthine synthase/0.589
2pchSAHDiphthine synthase/0.588
2p9dSAHDiphthine synthase/0.581
2hutSAHDiphthine synthase/0.579
2eldSAHDiphthine synthase/0.573
2ed3SAHDiphthine synthase/0.572
2hr8SAHDiphthine synthase/0.557
2pcaSAHDiphthine synthase/0.547
2ek4SAHDiphthine synthase/0.546
2owfSAHDiphthine synthase/0.525
2ejzSAHDiphthine synthase/0.502
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.488
2ou2ACOHistone acetyltransferase KAT5/0.477
4djhJDCKappa-type opioid receptor/0.470
1bwsNDPGDP-L-fucose synthase/0.467
1f8fNADBenzyl alcohol dehydrogenase/0.464
2rhgIGPTryptophan synthase alpha chain/0.458
3to6LYS_CMCHistone acetyltransferase ESA1/0.456
1xe55FEPlasmepsin-23.4.23.390.454
2givACOHistone acetyltransferase KAT8/0.451
2xhd7T9Glutamate receptor 2/0.450
1xddAAYIntegrin alpha-L/0.448
4djaFAD(6-4) photolyase/0.448
2y0mACOHistone acetyltransferase KAT8/0.447
1e7qNAPGDP-L-fucose synthase/0.446
1jipKTN6-deoxyerythronolide B hydroxylase/0.446
2a94AP0L-lactate dehydrogenase1.1.1.270.446
3h6vNS6Glutamate receptor 2/0.446
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.446
1c9k5GPBifunctional adenosylcobalamin biosynthesis protein CobU/0.444
3bg7FADPyranose 2-oxidase/0.443
3up5FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.443
1re7FOLDihydrofolate reductase1.5.1.30.442
1lbcCYZGlutamate receptor 2/0.441
1t9gFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.441
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.441
3gw9VNILanosterol 14-alpha-demethylase/0.441
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.441
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.441
2rcyNAPPyrroline-5-carboxylate reductase/0.440
3q43D66M1 family aminopeptidase3.4.110.440