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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2fjbSFDAdenylylsulfate reductase, subunit A (AprA)

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2fjbSFDAdenylylsulfate reductase, subunit A (AprA)/1.000
2fjdSFDAdenylylsulfate reductase, subunit A (AprA)/0.719
5c3jFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.475
3bg7FADPyranose 2-oxidase/0.471
3vqrFADPutative oxidoreductase/0.467
4udqFAD5-(hydroxymethyl)furfural oxidase/0.465
4udrFAD5-(hydroxymethyl)furfural oxidase/0.462
1d4dFADFumarate reductase flavoprotein subunit1.3.5.40.460
3ctyFADProbable thioredoxin reductase/0.460
5c2tFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.460
4ytnFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.458
1kf6FADFumarate reductase flavoprotein subunit1.3.5.40.456
2ywlFADThioredoxin reductase related protein/0.456
3kveFADL-amino-acid oxidase/0.456
4kx6FADFumarate reductase flavoprotein subunit1.3.5.40.454
2bi7FADUDP-galactopyranose mutase5.4.99.90.452
1ju2FAD(R)-mandelonitrile lyase 24.1.2.100.449
1galFADGlucose oxidase1.1.3.40.448
2babFADPutative aminooxidase/0.448
1e1lFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.446
1qo8FADFumarate reductase flavoprotein subunit/0.446
4echFADPolyamine oxidase FMS1/0.446
1d4cFADFumarate reductase flavoprotein subunit1.3.5.40.444
3cntFADPolyamine oxidase FMS1/0.444
5l3dFADLysine-specific histone demethylase 1A10.441