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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2f2uM77Rho-associated protein kinase 22.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2f2uM77Rho-associated protein kinase 22.7.11.11.000
3ncz3NCRho-associated protein kinase 12.7.11.10.545
2etrY27Rho-associated protein kinase 12.7.11.10.530
4fv6E57Mitogen-activated protein kinase 12.7.11.240.499
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.484
4l9i8PRRhodopsin kinase/0.472
3nynSGVG protein-coupled receptor kinase 62.7.11.160.468
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.463
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
3a8wATPProtein kinase C iota type2.7.11.130.449
4otiMI1Serine/threonine-protein kinase N1/0.449
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.446
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
1fvv107Cyclin-dependent kinase 22.7.11.220.444
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.443
3gu83GUDeath-associated protein kinase 12.7.11.10.441