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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.311

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3111.000
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.478
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.472
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.469
4gh5NADShort-chain dehydrogenase/reductase SDR/0.469
1xg5NAPDehydrogenase/reductase SDR family member 11/0.456
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.451
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.446
3d3wNAPL-xylulose reductase1.1.1.100.444
2dteNAIGlucose 1-dehydrogenase related protein/0.442
1u7tTDT3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.440
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.440
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.440
5jlaNADPutative short-chain dehydrogenase/reductase/0.440