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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2dxvSAHDiphthine synthase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2dxvSAHDiphthine synthase/1.000
2dxwSAHDiphthine synthase/0.906
2emrSAHDiphthine synthase/0.858
2eh5SAHDiphthine synthase/0.827
2dv7SAHDiphthine synthase/0.826
2ejkSAHDiphthine synthase/0.821
2e8sSAHDiphthine synthase/0.818
2eniSAHDiphthine synthase/0.818
2pcmSAHDiphthine synthase/0.815
2dsgSAHDiphthine synthase/0.804
2ehlSAHDiphthine synthase/0.802
2p6dSAHDiphthine synthase/0.802
2ek7SAHDiphthine synthase/0.801
2e8qSAHDiphthine synthase/0.797
2egsSAHDiphthine synthase/0.797
2emuSAHDiphthine synthase/0.794
2ed5SAHDiphthine synthase/0.791
2el0SAHDiphthine synthase/0.789
2dv4SAHDiphthine synthase/0.787
2ekaSAHDiphthine synthase/0.772
2eglSAHDiphthine synthase/0.769
2pb4SAHDiphthine synthase/0.759
2p6kSAHDiphthine synthase/0.756
2en5SAHDiphthine synthase/0.741
2p5cSAHDiphthine synthase/0.739
1wngSAHDiphthine synthase/0.737
2egbSAHDiphthine synthase/0.736
2e7rSAHDiphthine synthase/0.734
2huxSAHDiphthine synthase/0.728
2p2xSAHDiphthine synthase/0.723
2eleSAHDiphthine synthase/0.718
2owkSAHDiphthine synthase/0.717
2p5fSAHDiphthine synthase/0.710
2pcgSAHDiphthine synthase/0.705
2pb6SAHDiphthine synthase/0.701
2e16SAHDiphthine synthase/0.699
2eh2SAHDiphthine synthase/0.698
2dxxSAHDiphthine synthase/0.695
2pchSAHDiphthine synthase/0.694
2dv3SAHDiphthine synthase/0.693
2e08SAHDiphthine synthase/0.690
2owvSAHDiphthine synthase/0.686
2dsiSAHDiphthine synthase/0.685
2p6iSAHDiphthine synthase/0.670
2e8hSAHDiphthine synthase/0.667
1vceSAHDiphthine synthase/0.663
2pckSAHDiphthine synthase/0.657
2ek2SAHDiphthine synthase/0.653
2dekSAHDiphthine synthase/0.652
2hr8SAHDiphthine synthase/0.652
2pb5SAHDiphthine synthase/0.652
2pcaSAHDiphthine synthase/0.648
2eh4SAHDiphthine synthase/0.643
2e8rSAHDiphthine synthase/0.638
2hutSAHDiphthine synthase/0.637
2eeqSAHDiphthine synthase/0.635
2eldSAHDiphthine synthase/0.635
2huvSAHDiphthine synthase/0.632
2dv5SAHDiphthine synthase/0.631
2owgSAHDiphthine synthase/0.628
2owuSAHDiphthine synthase/0.627
2e4nSAHDiphthine synthase/0.625
2pciSAHDiphthine synthase/0.625
2p9dSAHDiphthine synthase/0.624
2z6rSAHDiphthine synthase/0.622
2e17SAHDiphthine synthase/0.618
2ek4SAHDiphthine synthase/0.613
2el3SAHDiphthine synthase/0.606
2p6lSAHDiphthine synthase/0.605
2ejjSAHDiphthine synthase/0.599
2ek3SAHDiphthine synthase/0.598
2e15SAHDiphthine synthase/0.593
2e07SAHDiphthine synthase/0.573
2huqSAHDiphthine synthase/0.569
2owfSAHDiphthine synthase/0.564
2dshSAHDiphthine synthase/0.538
2ed3SAHDiphthine synthase/0.515
2ejzSAHDiphthine synthase/0.503
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.459
3up5FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.459
1tqf32PBeta-secretase 13.4.23.460.456
2gjlFMNNitronate monooxygenase1.13.12.160.456
2q4bNAPUncharacterized protein At5g02240/0.455
1xe55FEPlasmepsin-23.4.23.390.454
2fxv5GPXanthine phosphoribosyltransferase2.4.2.220.454
3zh8C58Protein kinase C iota type2.7.11.130.453
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.452
3w6hAZMCarbonic anhydrase 14.2.1.10.451
3a3gDLZLumazine protein/0.450
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.449
2znnS44Peroxisome proliferator-activated receptor alpha/0.449
3tjzGNPADP-ribosylation factor 1/0.449
1bwsNDPGDP-L-fucose synthase/0.447
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.447
2q5g1FAPeroxisome proliferator-activated receptor delta/0.447
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.447
3q43D66M1 family aminopeptidase3.4.110.445
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.445
1bdlIM1Gag-Pol polyprotein3.4.23.160.444
1f8fNADBenzyl alcohol dehydrogenase/0.444
3m1vCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.444
3m1vCOMMethyl-coenzyme M reductase I subunit beta2.8.4.10.444
2gjnFMNNitronate monooxygenase1.13.12.160.443
3triNAPPyrroline-5-carboxylate reductase/0.443
5adhAPRAlcohol dehydrogenase E chain1.1.1.10.443
2g8yNADHydroxycarboxylate dehydrogenase B/0.442
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.441
3b70NAPEnoyl reductase LovC10.441
3lqfNADGalactitol dehydrogenase/0.441
4kb9G79Protease/0.441
1nvtNAPShikimate dehydrogenase (NADP(+))/0.440
2a94AP0L-lactate dehydrogenase1.1.1.270.440
2qbuSAHPrecorrin-2 methyltransferase/0.440
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.440
5dp2NAPCurF/0.440