Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
PDB ID | HET | Uniprot Name | EC Number |
---|---|---|---|
2cdz | 23D | Serine/threonine-protein kinase PAK 4 | 2.7.11.1 |
PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
---|---|---|---|---|---|
2cdz | 23D | Serine/threonine-protein kinase PAK 4 | 2.7.11.1 | 1.000 | |
1byg | STU | Tyrosine-protein kinase CSK | / | 0.488 | |
4ks8 | B49 | Serine/threonine-protein kinase PAK 6 | 2.7.11.1 | 0.487 | |
3w33 | W19 | Epidermal growth factor receptor | 2.7.10.1 | 0.465 | |
4yzc | STU | Serine/threonine-protein kinase/endoribonuclease IRE1 | 2.7.11.1 | 0.464 | |
4dit | 0KD | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.462 | |
4bib | IEO | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.454 | |
2hy8 | 1ST | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.453 | |
1eh4 | IC1 | Casein kinase I homolog 1 | 2.7.11.1 | 0.452 | |
4y95 | 746 | Tyrosine-protein kinase | / | 0.452 | |
3ama | SKE | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.447 | |
3cbl | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.447 | |
2x2l | X2L | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.446 | |
1rek | B8L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.445 | |
3say | OFT | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.445 | |
4bf2 | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.445 | |
1qcf | PP1 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.441 | |
2vu3 | LZE | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
3amb | VX6 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
3l1s | Z92 | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.441 | |
4y93 | 746 | Tyrosine-protein kinase | / | 0.440 |