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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.11.000
1bygSTUTyrosine-protein kinase CSK/0.488
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.487
3w33W19Epidermal growth factor receptor2.7.10.10.465
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.464
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.462
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.454
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.453
1eh4IC1Casein kinase I homolog 12.7.11.10.452
4y95746Tyrosine-protein kinase/0.452
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.447
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.446
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.445
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.445
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.441
2vu3LZECyclin-dependent kinase 22.7.11.220.441
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.441
4y93746Tyrosine-protein kinase/0.440