sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2ccu	2D9	Heat shock protein HSP 90-alpha

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
2ccu	2D9	Heat shock protein HSP 90-alpha	/	1.000
2vci	2GJ	Heat shock protein HSP 90-alpha	/	0.578
4fcq	2N6	Heat shock protein HSP 90-alpha	/	0.548
2wi5	ZZ5	Heat shock protein HSP 90-alpha	/	0.535
2vcj	2EQ	Heat shock protein HSP 90-alpha	/	0.530
2bsm	BSM	Heat shock protein HSP 90-alpha	/	0.528
2yi6	6QM	Heat shock protein HSP 90-alpha	/	0.521
4egh	0OY	Heat shock protein HSP 90-alpha	/	0.516
2uwd	2GG	Heat shock protein HSP 90-alpha	/	0.513
2yec	XQ0	Heat shock protein HSP 90-alpha	/	0.510
2wi1	ZZ2	Heat shock protein HSP 90-alpha	/	0.506
2ye4	2FY	Heat shock protein HSP 90-alpha	/	0.495
1osf	KOS	Heat shock protein HSP 90-alpha	/	0.479
1yet	GDM	Heat shock protein HSP 90-alpha	/	0.469
3q5l	KX2	Heat shock protein 83-1	/	0.446
2wer	RDC	ATP-dependent molecular chaperone HSP82	/	0.444
4aac	AAV	Mitogen-activated protein kinase 14	/	0.442
2xab	VHD	Heat shock protein HSP 90-alpha	/	0.440