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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2c9cATPPsp operon transcriptional activator

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2c9cATPPsp operon transcriptional activator/1.000
2c96ATPPsp operon transcriptional activator/0.506
4yduADPtRNA N6-adenosine threonylcarbamoyltransferase/0.483
3m0eATPTranscriptional regulator (NtrC family)/0.474
3dzdADPTranscriptional regulator (NtrC family)/0.466
1ht2ADPATP-dependent protease ATPase subunit HslU/0.458
1ny5ADPTranscriptional regulator (NtrC family)/0.458
4wq5ATPtRNA N6-adenosine threonylcarbamoyltransferase/0.458
4orkGDPBifunctional AAC/APH2.3.10.456
3mpaSB2Mitogen-activated protein kinase 14/0.454
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
1g41ADPATP-dependent protease ATPase subunit HslU/0.452
3njoP2MAbscisic acid receptor PYR1/0.449
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4h9tHL4Phosphotriesterase/0.449
4jia1K3Tyrosine-protein kinase JAK2/0.449
1i44ACPInsulin receptor2.7.10.10.447
1jlcFTCGag-Pol polyprotein2.7.7.490.447
2b9wFADPutative aminooxidase/0.447
4hvb19PPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447