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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2c4iBTNAvidin

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2c4iBTNAvidin/1.000
2aviBTNAvidin/0.531
1avdBTNAvidin/0.528
2uywBTNAvd protein/0.524
2fhnBNIAvidin-related protein 4/5/0.511
2rtgBTNStreptavidin/0.510
2fhlBNIAvidin-related protein 4/5/0.494
2izhBTNStreptavidin/0.489
3ry2BTNStreptavidin/0.487
1rxhBNIStreptavidin/0.483
2rtdBTNStreptavidin/0.483
2rtfBTNStreptavidin/0.483
2izlIMIStreptavidin/0.480
2izgBTNStreptavidin/0.476
2uz2BTNAvd protein/0.476
4dneDTBStreptavidin/0.473
2rteBTNStreptavidin/0.470
1swtBTNStreptavidin/0.465
2rtiGLLStreptavidin/0.464
4gdaBTNStreptavidin/0.463
4b4oNDPEpimerase family protein SDR39U1/0.460
2rtoIMIStreptavidin/0.459
3wznBTNStreptavidin/0.456
1stpBTNStreptavidin/0.454
2rtqIMIStreptavidin/0.454
2izkGLLStreptavidin/0.453
4bx7B4FStreptavidin/0.453
2izfBTNStreptavidin/0.450
2rtkGLLStreptavidin/0.450
1mk5BTNStreptavidin/0.449
2rtnIMIStreptavidin/0.449
1fwkADPHomoserine kinase2.7.1.390.443
2izjBTNStreptavidin/0.442
2y3fBTNStreptavidin/0.441
3h3qH13Collagen type IV alpha-3-binding protein/0.440