Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2c42TPPPyruvate synthase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2c42TPPPyruvate synthase/1.000
2c3p1TPPyruvate synthase/0.646
2pdaTPPPyruvate synthase/0.646
2c3oTPPPyruvate synthase/0.630
2uzaHTLPyruvate synthase/0.609
1kekHTLPyruvate synthase/0.589
2c3yHTLPyruvate synthase/0.546
2c3u2TPPyruvate synthase/0.519
1c3x8IGPurine nucleoside phosphorylase2.4.2.10.502
2x7hPFNProstaglandin reductase 310.469
4h6zACOAlpha-tubulin N-acetyltransferase 1/0.454
2ihuTP9N(2)-(2-carboxyethyl)arginine synthase/0.451
4y1bNAPAntE/0.451
1trkTPPTransketolase 12.2.1.10.450
2hxzH7JCathepsin S3.4.22.270.449
4fex0TOAminoglycoside 3'-phosphotransferase AphA1-IAB/0.448
5c4iTPPOxalate oxidoreductase subunit alpha/0.446
5c4iTPPOxalate oxidoreductase subunit beta/0.446
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.444
4hkfACOAlpha-tubulin N-acetyltransferase 1/0.442
1upcTPPN(2)-(2-carboxyethyl)arginine synthase/0.441
1z6tADPApoptotic protease-activating factor 1/0.441
4uugPXGBranched-chain amino acid aminotransferase, putative/0.441
1fm7DFVChalcone--flavonone isomerase 15.5.1.60.440
1h50FMNPentaerythritol tetranitrate reductase/0.440
3kr6UD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.440
4hy6FJ1Heat shock protein HSP 90-alpha/0.440
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.440