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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2bwg5GPGMP reductase 1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2bwg5GPGMP reductase 1/1.000
2ble5GPGMP reductase 1/0.532
4gh5NADShort-chain dehydrogenase/reductase SDR/0.474
1rbmKT5Trifunctional purine biosynthetic protein adenosine-32.1.2.20.464
2p5uNADUDP-glucose 4-epimerase/0.464
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.458
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.454
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.454
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.453
1xq6NAPUncharacterized protein At5g02240/0.452
2uuvFADAlkyldihydroxyacetonephosphate synthase2.5.1.260.451
2y8qADP5'-AMP-activated protein kinase subunit gamma-1/0.447
3ms421NGlycogen phosphorylase, muscle form2.4.1.10.445
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.443
1zemNADXylitol dehydrogenase/0.442
2wdzNADGalactitol dehydrogenase/0.442
4kl9NDPDihydrofolate reductase1.5.1.30.442
1jpaANPEphrin type-B receptor 22.7.10.10.441
3d3wNAPL-xylulose reductase1.1.1.100.441
3kpkFADSulfide-quinone reductase/0.441
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.441
3p7nFMNLight-activated DNA-binding protein EL222/0.441