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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2bf7HBIPteridine reductase 11.5.1.33

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2bf7HBIPteridine reductase 11.5.1.331.000
2bfpH4BPteridine reductase 11.5.1.330.660
1e92HBIPteridine reductase 11.5.1.330.650
3h4vDVPPteridine reductase 11.5.1.330.607
2bfaCB3Pteridine reductase 11.5.1.330.582
2qhxFE1Pteridine reductase 11.5.1.330.563
2bfmTOPPteridine reductase 11.5.1.330.549
1p33MTXPteridine reductase 11.5.1.330.484
3h4vNAPPteridine reductase 11.5.1.330.471
1e7wMTXPteridine reductase 11.5.1.330.445