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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.146

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1461.000
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.560
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.534
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.492
4dc1NDPPutative ketoacyl reductase1.3.10.487
1xg5NAPDehydrogenase/reductase SDR family member 11/0.482
1w4zNAPPutative ketoacyl reductase1.3.10.472
4hwkNAPSepiapterin reductase1.1.1.1530.472
1ae1NAPTropinone reductase 1/0.470
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.470
1x7hNDPPutative ketoacyl reductase1.3.10.468
3sjuNDPKeto reductase/0.467
4qecNAPElxO/0.466
3qrwNDPPutative ketoacyl reductase1.3.10.464
4j7uNAPSepiapterin reductase1.1.1.1530.461
1x7gNAPPutative ketoacyl reductase1.3.10.458
1xkqNDPUncharacterized protein/0.456
3toxNAPPutative oxidoreductase/0.455
4j7xNAPSepiapterin reductase1.1.1.1530.455
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.451
3p19NDPPutative blue fluorescent protein/0.450
5jlaNADPutative short-chain dehydrogenase/reductase/0.450
2yutNAPPutative short-chain oxidoreductase/0.447
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.444
1snyNAPLD36273p/0.443
1oaaNAPSepiapterin reductase1.1.1.1530.442
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.442