sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1xqp	8HG	N-glycosylase/DNA lyase

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
1xqp	8HG	N-glycosylase/DNA lyase	/	1.000
1ay0	TPP	Transketolase 1	2.2.1.1	0.467
4g2g	TDH	Mycocyclosin synthase	1.14.21.9	0.453
1qrp	HH0	Pepsin A-4	3.4.23.1	0.452
1txt	CAA	HMG-CoA synthase	/	0.448
1y2e	5DE	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.447
1zdw	FLV	Prenyltransferase	/	0.447
2nmt	MIM	Glycylpeptide N-tetradecanoyltransferase	2.3.1.97	0.446
3giy	FMN	(S)-mandelate dehydrogenase	1.1.99.31	0.444
3uzw	NAP	3-oxo-5-beta-steroid 4-dehydrogenase	/	0.444
1ps9	MDE	2,4-dienoyl-CoA reductase	1.3.1.34	0.442
4cjx	9L9	C-1-tetrahydrofolate synthase, cytoplasmic, putative	/	0.442
1pq9	44B	Oxysterols receptor LXR-beta	/	0.440
2ed3	SAH	Diphthine synthase	/	0.440
2pfg	DDD	Carbonyl reductase [NADPH] 1	1.1.1.184	0.440