sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1w6j	R71	Lanosterol synthase	5.4.99.7

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
1w6j	R71	Lanosterol synthase	5.4.99.7	1.000
1o6q	R17	Squalene--hopene cyclase	4.2.1.129	0.454
3fap	ARD	Peptidyl-prolyl cis-trans isomerase FKBP1A	5.2.1.8	0.454
3fap	ARD	Serine/threonine-protein kinase mTOR	2.7.11.1	0.454
1h35	R01	Squalene--hopene cyclase	4.2.1.129	0.451
1ni4	TPP	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial	1.2.4.1	0.447
1ni4	TPP	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	1.2.4.1	0.447
1u65	CP0	Acetylcholinesterase	3.1.1.7	0.441
1x1b	SAH	C-20 methyltransferase	/	0.441
4bfz	ZVZ	Pantothenate kinase	2.7.1.33	0.441
1h36	R88	Squalene--hopene cyclase	4.2.1.129	0.440