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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1w2xRCPAcetyl-CoA carboxylase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1w2xRCPAcetyl-CoA carboxylase/1.000
3h0sB38Acetyl-CoA carboxylase/0.566
3tz3B36Acetyl-CoA carboxylase/0.545
3tvuB37Acetyl-CoA carboxylase/0.533
3pgqGY3Acetyl-CoA carboxylase/0.532
3da24MDCarbonic anhydrase 134.2.1.10.466
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.466
1fm9570Peroxisome proliferator-activated receptor gamma/0.463
2y8lADP5'-AMP-activated protein kinase subunit gamma-1/0.454
2ath3EAPeroxisome proliferator-activated receptor gamma/0.452
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.451
4v2gITCTetracycline repressor protein class D/0.449
2hmaSAMtRNA-specific 2-thiouridylase MnmA/0.447
4q71FADBifunctional protein PutA/0.447
3uzcT4EAdenosine receptor A2a/0.445
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.444
2igoFADPyranose 2-oxidase/0.443
3ajrNADNDP-sugar epimerase/0.443
4ipw1G7Mycocyclosin synthase1.14.21.90.442
2givACOHistone acetyltransferase KAT8/0.441
2nu9COASuccinate--CoA ligase [ADP-forming] subunit alpha6.2.1.50.441
3zuyTCHTransporter/0.441
3ad9NADSubunit alpha of sarocosine oxidase/0.440
3zuxTCHTransporter/0.440
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.440