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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1rc4DDFDihydrofolate reductase1.5.1.3

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1rc4DDFDihydrofolate reductase1.5.1.31.000
1rf7DHFDihydrofolate reductase1.5.1.30.545
1re7FOLDihydrofolate reductase1.5.1.30.521
1ddsMTXDihydrofolate reductase1.5.1.30.496
1ddrMTXDihydrofolate reductase1.5.1.30.491
1jolFFODihydrofolate reductase1.5.1.30.491
4ej1FOLDihydrofolate reductase1.5.1.30.489
2d0kFOLDihydrofolate reductase1.5.1.30.479
1draMTXDihydrofolate reductase1.5.1.30.478
2drcMTXDihydrofolate reductase1.5.1.30.477
3och2MXDihydrofolate reductase1.5.1.30.475
1jomFFODihydrofolate reductase1.5.1.30.471
4dfrMTXDihydrofolate reductase1.5.1.30.471
4x5jFOLDihydrofolate reductase1.5.1.30.468
1rx7FOLDihydrofolate reductase1.5.1.30.467
4i1nFOLDihydrofolate reductase1.5.1.30.467
1dyjDDFDihydrofolate reductase1.5.1.30.465
1rb3MTXDihydrofolate reductase1.5.1.30.463
1dhjMTXDihydrofolate reductase1.5.1.30.461
5hi6MTXDihydrofolate reductase/0.451
1rx4DDFDihydrofolate reductase1.5.1.30.450
4cd2FOLDihydrofolate reductase1.5.1.30.450
4i13FOLDihydrofolate reductase1.5.1.30.449
4x5iFOLDihydrofolate reductase1.5.1.30.449
1rx5DDFDihydrofolate reductase1.5.1.30.446
1rd7FOLDihydrofolate reductase1.5.1.30.441
1rx6DDFDihydrofolate reductase1.5.1.30.440