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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.11.000
5e8ySTUTGF-beta receptor type-22.7.11.300.508
3bu5ATPInsulin receptor2.7.10.10.472
3hmm855TGF-beta receptor type-12.7.11.300.468
3gu7ADPDeath-associated protein kinase 12.7.11.10.464
4deeADPAurora kinase A2.7.11.10.463
3w32W32Epidermal growth factor receptor2.7.10.10.460
1pmn984Mitogen-activated protein kinase 102.7.11.240.459
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.459
4jboWPHAurora kinase A2.7.11.10.458
3gu83GUDeath-associated protein kinase 12.7.11.10.457
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.456
5cnoANPEpidermal growth factor receptor2.7.10.10.456
4lfiGNPCasein kinase II subunit alpha2.7.11.10.455
3nieANPMitogen-activated protein kinase/0.452
5dosATPAurora kinase A2.7.11.10.450
3i60E86Mitogen-activated protein kinase 12.7.11.240.448
3cgfJNFMitogen-activated protein kinase 102.7.11.240.447
1qmzATPCyclin-dependent kinase 22.7.11.220.446
3w33W19Epidermal growth factor receptor2.7.10.10.446
4j95ACPFibroblast growth factor receptor 2/0.444
4k33ACPFibroblast growth factor receptor 32.7.10.10.443
4xlvACPInsulin receptor2.7.10.10.443
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.442
4dymIYZActivin receptor type-12.7.11.300.441
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.441
5e92ANPTGF-beta receptor type-22.7.11.300.441
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.440