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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1o1t2NHProtein farnesyltransferase subunit beta2.5.1.58

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1o1t2NHProtein farnesyltransferase subunit beta2.5.1.581.000
1o1s1NHProtein farnesyltransferase subunit beta2.5.1.580.801
3ksqZ96Protein farnesyltransferase subunit beta2.5.1.580.742
2r2lPB9Protein farnesyltransferase subunit beta2.5.1.580.702
1sa5BMVProtein farnesyltransferase subunit beta2.5.1.580.654
1ld7U66Protein farnesyltransferase subunit beta2.5.1.580.645
3e30ED4Protein farnesyltransferase subunit beta2.5.1.580.638
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.638
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.635
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.635
2iejS48Protein farnesyltransferase subunit beta2.5.1.580.630
3kslSZHProtein farnesyltransferase subunit beta2.5.1.580.628
2f0y3MNProtein farnesyltransferase subunit beta2.5.1.580.616
3sfy3FYUncharacterized protein/0.615
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.613
1s63778Protein farnesyltransferase subunit beta2.5.1.580.606
1ni1HFPProtein farnesyltransferase subunit beta2.5.1.580.602
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.598
1n95HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.597
1n95HFPProtein farnesyltransferase subunit beta2.5.1.580.597
1nl4HFPProtein farnesyltransferase subunit beta2.5.1.580.597
1sa4JANProtein farnesyltransferase subunit beta2.5.1.580.595
1mzcBNEProtein farnesyltransferase subunit beta2.5.1.580.586
3q7fED2Uncharacterized protein/0.580
4gtr7TRProtein farnesyltransferase subunit beta2.5.1.580.534
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.475
2vutNADNitrogen metabolite repression protein nmrA/0.458
4gtv7TRGeranylgeranyl transferase type-2 subunit beta2.5.1.600.455
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
1n4pCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.444