sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1nw6	SFG	Modification methylase RsrI	2.1.1.72

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
1nw6	SFG	Modification methylase RsrI	2.1.1.72	1.000
1nw5	SAM	Modification methylase RsrI	2.1.1.72	0.780
1eg2	MTA	Modification methylase RsrI	2.1.1.72	0.556
3swr	SFG	DNA (cytosine-5)-methyltransferase 1	2.1.1.37	0.462
4rtr	SAM	DNA adenine methylase	2.1.1.72	0.458
4gbe	SAH	DNA adenine methylase	2.1.1.72	0.457
2ore	SAH	DNA adenine methylase	2.1.1.72	0.450
2zif	SAM	Methyltransferase	/	0.449
4rtp	SAM	DNA adenine methylase	2.1.1.72	0.448
3ldf	SAH	Uncharacterized protein	/	0.447
4rts	SAM	DNA adenine methylase	2.1.1.72	0.446
1boo	SAH	Modification methylase PvuII	2.1.1.113	0.443
2ibt	NEA	Modification methylase TaqI	2.1.1.72	0.442
3pt9	SAH	DNA (cytosine-5)-methyltransferase 1	2.1.1.37	0.441
9mht	SAH	Modification methylase HhaI	2.1.1.37	0.441
2g1p	SAH	DNA adenine methylase	2.1.1.72	0.440
2r43	G3G	Gag-Pol polyprotein	3.4.23.16	0.440
4anx	534	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.440
4rtl	SFG	DNA adenine methylase	2.1.1.72	0.440