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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1m75CAAHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.35

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1m75CAAHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.351.000
1f0yCAAHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.605
1m76CAAHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.570
2ozuACOHistone acetyltransferase KAT6A/0.465
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.455
3gqvNAPEnoyl reductase LovC10.455
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.454
3b70NAPEnoyl reductase LovC10.454
1xe55FEPlasmepsin-23.4.23.390.453
4g7gVFVLanosterol 14-alpha-demethylase/0.453
1bwsNDPGDP-L-fucose synthase/0.452
2uxoTACHTH-type transcriptional regulator TtgR/0.448
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.448
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.445
3qwbNDPProbable quinone oxidoreductase1.6.5.50.445
4hwkNAPSepiapterin reductase1.1.1.1530.444
1dhjMTXDihydrofolate reductase1.5.1.30.442
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.442
3b6zCO7Enoyl reductase LovC10.442
4cd2FOLDihydrofolate reductase1.5.1.30.442
3cgdNADCoenzyme A disulfide reductase/0.440
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.440
4l8u9AZSerum albumin/0.440