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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1lhvNOGSex hormone-binding globulin

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1lhvNOGSex hormone-binding globulin/1.000
1d2sDHTSex hormone-binding globulin/0.552
1f5fDHTSex hormone-binding globulin/0.503
1lhnAONSex hormone-binding globulin/0.480
1fp2HMOIsoflavone-7-O-methyltransferase 82.1.1.1500.474
3gwfFADCyclohexanone monooxygenase/0.468
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.463
1t1rIMB1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.460
3vrwYS5Vitamin D3 receptor/0.458
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
1bygSTUTyrosine-protein kinase CSK/0.449
3zk5Z18Cytochrome P450 monooxygenase PikC/0.449
4iaq2GM5-hydroxytryptamine receptor 1B/0.447
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
3vetADPnebramycin 5' synthase6.1.2.20.446
3vt5YI2Vitamin D3 receptor/0.446
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.446
4ubsDIFPentalenic acid synthase1.14.15.110.446
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
3vtcTK3Vitamin D3 receptor/0.445
4hvb19PPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
2bx8AZQSerum albumin/0.444
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.443
1kdkDHTSex hormone-binding globulin/0.442
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.442
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.442
2zlcVDXVitamin D3 receptor/0.442
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.440
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.440