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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1jstATPCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1jstATPCyclin-dependent kinase 22.7.11.221.000
1qmzATPCyclin-dependent kinase 22.7.11.220.558
4bcmT7ZCyclin-dependent kinase 22.7.11.220.498
4ii5ADPCyclin-dependent kinase 22.7.11.220.496
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.490
3my5RFZCyclin-dependent kinase 22.7.11.220.488
4eooATPCyclin-dependent kinase 22.7.11.220.484
1fvv107Cyclin-dependent kinase 22.7.11.220.482
2cjmATPCyclin-dependent kinase 22.7.11.220.472
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.467
4ix5ANPUncharacterized protein/0.466
4ez50RSCyclin-dependent kinase 62.7.11.220.464
3bu5ATPInsulin receptor2.7.10.10.463
2w17I19Cyclin-dependent kinase 22.7.11.220.458
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.456
4qnyANPMitogen activated protein kinase, putative/0.454
2vu3LZECyclin-dependent kinase 22.7.11.220.453
3nux3NVCyclin-dependent kinase 62.7.11.220.452
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.451
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.450
4i3zADPCyclin-dependent kinase 22.7.11.220.448
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.447
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.445
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.445
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.443
2vv9IM9Cyclin-dependent kinase 22.7.11.220.441