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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1jscTPPAcetolactate synthase catalytic subunit, mitochondrial2.2.1.6

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1jscTPPAcetolactate synthase catalytic subunit, mitochondrial2.2.1.61.000
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.453
2rhrEMOPutative ketoacyl reductase1.3.10.453
4q71FADBifunctional protein PutA/0.448
3eyaTDPPyruvate dehydrogenase [ubiquinone]1.2.5.10.447
1x2hLPALipoate-protein ligase A6.3.1.200.442
3p62FMNPentaerythritol tetranitrate reductase/0.440