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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1jmhUMPThymidylate synthase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1jmhUMPThymidylate synthase/1.000
1tsvUMPThymidylate synthase/0.572
1jmfUMPThymidylate synthase/0.561
1thyUMPThymidylate synthase/0.560
2g8aUMPThymidylate synthase/0.542
1njbUMPThymidylate synthase/0.537
1tslA15Thymidylate synthase/0.520
1njdUMPThymidylate synthase/0.518
1jmgUMPThymidylate synthase/0.517
1vzdCB3Thymidylate synthase/0.515
1bp6UMPThymidylate synthase/0.513
1njaDCMThymidylate synthase/0.506
1jmiUMPThymidylate synthase/0.505
2g86UMPThymidylate synthase/0.503
2g89UMPThymidylate synthase/0.494
1tsyUMPThymidylate synthase/0.491
2tdmUMPThymidylate synthase/0.491
2vetUMPThymidylate synthase/0.488
1bidUMPThymidylate synthase/0.480
1bp0UMPThymidylate synthase/0.480
1njeDCMThymidylate synthase/0.480
1aobDDUThymidylate synthase/0.468
2g8dUMPThymidylate synthase/0.465
1bpjUMPThymidylate synthase/0.462
1njcDCMThymidylate synthase/0.459
1f4eTPRThymidylate synthase/0.458
1bduDURThymidylate synthase/0.456
1lcbTMPThymidylate synthase/0.454
1vzaUMPThymidylate synthase/0.453
1vzbUMPThymidylate synthase/0.453
3bgxTMPThymidylate synthase/0.450
1lcbDHFThymidylate synthase/0.447
1tsxUMPThymidylate synthase/0.444