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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1drbMTXDihydrofolate reductase1.5.1.3

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1drbMTXDihydrofolate reductase1.5.1.31.000
3drcMTXDihydrofolate reductase1.5.1.30.710
1dhjMTXDihydrofolate reductase1.5.1.30.615
1rb3MTXDihydrofolate reductase1.5.1.30.604
1dhiMTXDihydrofolate reductase1.5.1.30.600
4dfrMTXDihydrofolate reductase1.5.1.30.600
3och2MXDihydrofolate reductase1.5.1.30.599
1draMTXDihydrofolate reductase1.5.1.30.598
1ddrMTXDihydrofolate reductase1.5.1.30.580
2drcMTXDihydrofolate reductase1.5.1.30.576
1ddsMTXDihydrofolate reductase1.5.1.30.564
1jolFFODihydrofolate reductase1.5.1.30.560
1tdrMTXDihydrofolate reductase1.5.1.30.556
1dyjDDFDihydrofolate reductase1.5.1.30.552
1re7FOLDihydrofolate reductase1.5.1.30.528
5hi6MTXDihydrofolate reductase/0.527
4cd2FOLDihydrofolate reductase1.5.1.30.503
1rb2FOLDihydrofolate reductase1.5.1.30.497
1dyiFOLDihydrofolate reductase1.5.1.30.482
1dyhDZFDihydrofolate reductase1.5.1.30.465
4x5iFOLDihydrofolate reductase1.5.1.30.459
1rf7DHFDihydrofolate reductase1.5.1.30.453
4ele31IDihydrofolate reductase/0.453
1rd7FOLDihydrofolate reductase1.5.1.30.444
4x5jFOLDihydrofolate reductase1.5.1.30.443