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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1dirNADDihydropteridine reductase1.5.1.34

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1dirNADDihydropteridine reductase1.5.1.341.000
1dhrNADDihydropteridine reductase1.5.1.340.594
1hdrNADDihydropteridine reductase1.5.1.340.522
3orfNADDihydropteridine reductase1.5.1.340.503
3q43D66M1 family aminopeptidase3.4.110.471
1bwsNDPGDP-L-fucose synthase/0.467
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.467
3rudNADUDP-N-acetylglucosamine 4-epimerase/0.464
3ig6438Urokinase-type plasminogen activator3.4.21.730.457
3b6zCO7Enoyl reductase LovC10.456
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.453
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.452
2gjlFMNNitronate monooxygenase1.13.12.160.450
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.446
4a1zADPKinesin-like protein KIF11/0.445
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.445
4eji0QACytochrome P450 2A131.14.14.10.444
3gobHXXDdmC/0.443
3tjzGNPADP-ribosylation factor 1/0.443
4h3f10OBeta-secretase 13.4.23.460.443
1gqtACPRibokinase/0.441
4eudCOASuccinyl-CoA:acetate CoA-transferase/0.440
4h3j10WBeta-secretase 13.4.23.460.440