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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1akbPPDAspartate aminotransferase, mitochondrial2.6.1.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1akbPPDAspartate aminotransferase, mitochondrial2.6.1.11.000
1akcPPEAspartate aminotransferase, mitochondrial2.6.1.10.667
4dbc3QPAspartate aminotransferase2.6.1.10.600
1toiHCIAspartate aminotransferase2.6.1.10.589
1ivrCBAAspartate aminotransferase, mitochondrial2.6.1.10.584
1mapKETAspartate aminotransferase, mitochondrial2.6.1.10.581
1cq7PY5Aspartate aminotransferase2.6.1.10.579
1maqPGUAspartate aminotransferase, mitochondrial2.6.1.10.568
1cq8PY6Aspartate aminotransferase2.6.1.10.561
1tojHCIAspartate aminotransferase2.6.1.10.560
3qpg3QPAspartate aminotransferase2.6.1.10.551
1cq6PY4Aspartate aminotransferase2.6.1.10.532
1ahgTYR_PLPAspartate aminotransferase2.6.1.10.515
1ascNPLAspartate aminotransferase2.6.1.10.500
3e6eDCSAlanine racemase/0.464
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.454
4bb3KKAIsopenicillin N synthase1.21.3.10.444
2oapANPType II secretion system protein (GspE-2)/0.442
3i0pNADMalate dehydrogenase, putative/0.442
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.441
1rftPXMPyridoxal kinase2.7.1.350.441
3m2uCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.440
4e2yJHZMethyltransferase/0.440